A mathematically derived, continuously updated personal health index for cancer patients on active treatment. Not population averages — your calibrated reference point, updated daily.
Mathematical Foundation
NSI is not a symptom tracker or a wearable dashboard. It is a composite clinical intelligence model — built from seven evidence-weighted dimensions that interact, condition each other, and update continuously.
A lab value on cycle day 1 carries different clinical meaning than the same value on day 10 — the expected nadir. NSI conditions every measurement against where you are in the treatment cycle, so the score reflects clinical reality, not raw numbers.
Conditioned on your cycle dayCEA at 15 ng/mL and falling is not the same clinical picture as 15 ng/mL and rising. NSI captures direction and rate of change — the derivative of each dimension — and encodes it into the score. A trend matters more than a snapshot.
Direction is built into the modelNSI is calibrated to your biomarkers, your treatment line, your metastatic pattern, and your history — not population averages. The score means something different for a treatment-naïve patient than for someone in cycle 81. That difference is the point.
Your body. Your reference.NSI integrates vitals, labs, imaging, biomarkers, activity, symptoms, and wellbeing into a single continuous composite score. Each dimension carries an evidence-based weight, and they fuse through a weighted geometric mean — so a single failing domain can't hide behind strong ones.
Seven domains, fused — not averagedThe Problem
Oncology visits happen every 2–4 weeks. In between, patients are on their own — with no calibrated reference point, no integrated view, and no way to know when something needs attention.
Labs are in one portal, imaging in another, symptom notes in a third. No one — not even your oncologist — has a single real-time view of how you're doing between visits.
CEA, WBC, SpO₂, heart rate, step count, and distress score are never evaluated together. Every dimension is siloed. The whole patient is never seen at once.
Without a personal reference point, patients can't distinguish expected side effects from warning signs. Anxiety fills the vacuum where data should be.
This is not a failure of care — it is a structural gap. NOESIS is the first platform designed to close it.
NSI integrates your vitals, labs, imaging, biomarkers, function, symptoms, and wellbeing into a single 0–100 score — updated continuously, not just when you see your oncologist.
NOESIS surfaces your labs and vitals alongside the story they tell — not just the raw value, but where it sits in your personal range and whether it's moving in the right direction.
The live potential model calculates the measurable impact of specific actions on your NSI — calibrated to your clinical profile and graded by published evidence strength.
Standard oncology statistics describe average patients. NSI instead tracks the direction and speed of your own picture — and flags when the trend turns, often before a single lab would. It's a trajectory and early-warning aid, not a prediction of how your story ends.
NSI Data Pipeline
Epic FHIR alone covers 63% of NSI total weight in a single authorization. Full connection — EHR + wearable — exceeds 90% coverage.
How It Works
Link your EHR, oncology portal, labs, and wearables. Epic FHIR alone covers 63% of NSI dimensions in one authorization — no manual entry required.
Your NSI updates between appointments. Follow 7 dimensions, your trend chart, and what's driving your score — in plain language, not raw lab values.
Know when to call your care team, when to hold, and what specific actions can improve your score. No more guessing. No more anxiety in the gap.
See It In Action
Watch how scattered signals become one score — and one score becomes a clear next action. Press play for a narrated walkthrough of the whole loop.
Press play inside the demo to start the narration — or open the full demo ↗
The Objective
Why collapsing a whole clinical picture into a single situational-awareness number changes what patients, caregivers, and clinicians can do between visits.
Anchored in Established Medicine
The seven dimensions aren't invented. Each maps to a validated clinical tool — so any score can be opened and explained in language that belongs to you, not only to the clinic.
National Early Warning Score — vital-sign physiology (HR, SpO₂, BP).
Neutrophil–infection risk, plus standard lab reference ranges.
Tumour burden and response, read from imaging.
Tumour-marker velocity and distance from nadir (e.g. CEA).
Performance-status scale for everyday function.
Graded symptom & toxicity burden.
Distress Thermometer — patient-reported, weighed alongside the labs.
Every score is auditable: open it and see which dimension is limiting it, and why — and the same inputs always produce the same result.
A fresh SpO₂ of 88% forces the band to red — even if the composite reads “Stable.” The most dangerous signal always wins.
Danger Is Never Averaged Away
A parallel safety layer sits beside the score. When one channel is in a danger range — and the reading is recent enough to trust — the band is forced to red, and the message becomes the only one that matters.
Freshness-gated — vitals within 3 days, labs within 14 — so a stale clinic reading can’t false-alarm; a stale danger value surfaces a “re-check” note instead.
Measured Against the Standard of Care
From the same inputs, NSI shows up next to NEWS2 and ECOG — so an earlier warning and a fuller picture are things you can see, not things we assert.
Single-axis tools can read “fine” while a non-vitals domain is quietly failing. Because NSI fuses all seven — and can’t average danger away — it flags the drift first.
Illustrative, not proof: a retrospective single-patient (n = 1) audit. Formal cohort validation is the stated next step — and until it’s done, we say so plainly.
Market Opportunity
At any given time, more than 600,000 Americans are on active systemic cancer therapy — navigating treatment without a continuous intelligence platform. That gap is the market.
CMS established RPM reimbursement (CPT 99453–99458) for chronic and complex conditions. NOESIS is designed to operate within this framework — creating a complementary revenue stream for participating oncology practices and a clear adoption incentive.
The CMS Innovation Center's Enhancing Oncology Model (EOM, 2023) requires participating practices to implement electronic patient-reported outcome monitoring as a mandatory transformation element. NOESIS is positioned as an EOM-compliant solution — turning a compliance requirement into clinical value.
For Patients
Not population averages. A reference point calibrated to your body, your treatment line, and your history.
For Clinicians
Continuous patient data means you arrive at every appointment already knowing the story. Zero overhead added to your workflow.
Why We Exist
NOESIS was founded by a patient who spent years navigating the gap firsthand — living with serious illness and discovering that modern oncology has no mechanism for continuous visibility between appointments. The anxiety of not knowing. The uncertainty of interpreting every symptom alone. We built NOESIS because every patient deserves a calibrated reference point — every day, not just every few weeks.
Our Mission
Make continuous health intelligence accessible to every patient living with cancer — giving them the visibility, agency, and confidence to navigate treatment on their own terms.
Early Access
NOESIS is launching with select clinical sites in late 2026. Join the early access list — whether you're a patient, caregiver, oncologist, or practice administrator.
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